The big 12 is set up to win the MNC and the Heisman if there isn't too much canabalism. Seriously, taking the burnt orange glasses off for a moment, if either Texas, OU, or Mizzou wins the Big 12 undefeated or with a single loss, they will be in the title game and their QB should win thhe Heisman.
Here's why. If OU wins out they will have beat Texas, or Tech, or both, and Mizzou in the title game. Mizzou will have to beat Texas one of two times or OU. Texas will have to beat OU and Mizzou once or twice. Either way it should lead to the title game and the Heisman.