I went to VIN a week or so ago for the first time. Wasn't all that impressed. I'd agree with Striphouse or Bank if you want to be truly "downtown". If you want just a minute or two oustide the boundries of downtown, I'd do Gravitas on Taft, Monarch at Hotel ZaZa, or Catalan on Washington.
Cava Bistro on Main and Congress is very good. Its another of Mia Bella's sister restaurants. Ibiza is great, although just outside of downtown. Strip House is good too.
Strip House and Vic and Anthony's are my favorites downtown, but that's because I love steakhouses. The bar at Strip House is better, if I remember correctly. I have heard only good things about Ibiza as well.
I tried Reef - nice seafood place. I wasn't blown away- there were a couple menu items they ran out of which were my #1 and #2 choice though, so that may have been part of it. Everyone else I was with loved their meal- excellent salmon dish and a really good surf and turf.